	   SnapGene      *cgggcgttgttctttttaacttcaggcgggttacaatagtttccagtaagtattctggaggctgcatccatgacacaggcaaacctgagcgaaaccctgttcaaaccccgctttaaacatcctgaaacctcgacgctagtccgccgctttaatcacggcgcacaaccgcctgtgcagtcggcccttgatggtaaaaccatccctcactggtatcgcatgattaaccgtctgatgtggatctggcgcggcattgacccacgcgaaatcctcgacgtccaggcacgtattgtgatgagcgatgccgaacgtaccgacgatgatttatacgatacggtgattggctaccgtggcggcaactggatttatgagtgggccccggatctttgtgaaggaaccttacttctgtggtgtgacataattggacaaactacctacagagatttaaagctctaaggtaaatataaaatttttaagtgtataatgtgttaaactactgattctaattgtttgtgtattttagattccaacctatggaactgatgaatgggagcagtggtggaatgcctttaatgaggaaaacctgttttgctcagaagaaatgccatctagtgatgatgaggctactgctgactctcaacattctactcctccaaaaaagaagagaaaggtagaagaccccaaggactttccttcagaattgctaagttttttgagtcatgctgtgtttagtaatagaactcttgcttgctttgctatttacaccacaaaggaaaaagctgcactgctatacaagaaaattatggaaaaatattctgtaacctttataagtaggcataacagttataatcataacatactgttttttcttactccacacaggcatagagtgtctgctattaataactatgctcaaaaattgtgtacctttagctttttaatttgtaaaggggttaataaggaatatttgatgtatagtgccttgactagagatcataatcagccataccacatttgtagaggttttacttgctttaaaaaacctcccacacctccccctgaacctgaaacataaaatgaatgcaattgttgttgttaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctggatcaactggataactcaagctaaccaaaatcatcccaaacttcccaccccataccctattaccactgccaattacctgtggtttcatttactctaaacctgtgattcctctgaattattttcattttaaagaaattgtatttgttaaatatgtactacaaacttagtagttggaagggctaattcactcccaaagaagacaagatatccttgatctgtggatctaccacacacaaggctacttccctgattagcagaactacacaccagggccaggggtcagatatccactgacctttggatggtgctacaagctagtaccagttgagccagataaggtagaagaggccaataaaggagagaacaccagcttgttacaccctgtgagcctgcatgggatggatgacccggagagagaagtgttagagtggaggtttgacagccgcctagcatttcatcacgtggcccgagagctgcatccggagtacttcaagaactgctgatatcgagcttgctacaagggactttccgctggggactttccagggaggcgtggcctgggcgggactggggagtggcgagccctcagatcctgcatataagcagctgctttttgcctgtactgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtggcgcccgaacagggacttgaaagcgaaagggaaaccagaggagctctctcgacgcaggactcggcttgctgaagcgcgcacggcaagaggcgaggggcggcgactggtgagtacgccaaaaattttgactagcggaggctagaaggagagagatgggtgcgagagcgtcagtattaagcgggggagaattagatcgcgatgggaaaaaattcggttaaggccagggggaaagaaaaaatataaattaaaacatatagtatgggcaagcagggagctagaacgattcgcagttaatcctggcctgttagaaacatcagaaggctgtagacaaatactgggacagctacaaccatcccttcagacaggatcagaagaacttagatcattatataatacagtagcaaccctctattgtgtgcatcaaaggatagagataaaagacaccaaggaagctttagacaagatagaggaagagcaaaacaaaagtaagaccaccgcacagcaagcggccggccgctgatcttcagacctggaggaggagatatgagggacaattggagaagtgaattatataaatataaagtagtaaaaattgaaccattaggagtagcacccaccaaggcaaagagaagagtggtgcagagagaaaaaagagcagtgggaataggagctttgttccttgggttcttgggagcagcaggaagcactatgggcgcagcgtcaatgacgctgacggtacaggccagacaattattgtctggtatagtgcagcagcagaacaatttgctgagggctattgaggcgcaacagcatctgttgcaactcacagtctggggcatcaagcagctccaggcaagaatcctggctgtggaaagatacctaaaggatcaacagctcctggggatttggggttgctctggaaaactcatttgcaccactgctgtgccttggaatgctagttggagtaataaatctctggaacagatttggaatcacacgacctggatggagtgggacagagaaattaacaattacacaagcttaatacactccttaattgaagaatcgcaaaaccagcaagaaaagaatgaacaagaattattggaattagataaatgggcaagtttgtggaattggtttaacataacaaattggctgtggtatataaaattattcataatgatagtaggaggcttggtaggtttaagaatagtttttgctgtactttctatagtgaatagagttaggcagggatattcaccattatcgtttcagacccacctcccaaccccgaggggacccgacaggcccgaaggaatagaagaagaaggtggagagagagacagagacagatccattcgattagtgaacggatctcgacggtatcgccaaatggcagtattcatccacaattttaaaagaaaaggggggattggggggtacagtgcaggggaaagaatagtagacataatagcaacagacatacaaactaaagaattacaaaaacaaattacaaaaattcaaaattttcgggtttattacagggacagcagagatccagtttggatcgataagcttgatatcgaattcggagcactgtcctccgaacgtcggagcactgtcctccgaacgtcggagcactgtcctccgaacgtcggagcactgtcctccgaacggagcatgtcctccgaacgtcggagcactgtcctccgaacgactagttaggcgtgtacggtgggaggcctatataagcagagctcgtttagtgaaccgtcagatcgcctggagacgccatccacgctgttttgacctccatagaagacaccgggaccgatccagcctctcgacattcgttggatcatgagcgagctgattaaggagaacatgcacatgaagctgtacatggagggcaccgtggacaaccatcacttcaagtgcacatccgagggcgaaggcaagccctacgagggcacccagaccatgagaatcaaggtggtcgagggcggccctctccccttcgccttcgacatcctggctactagcttcctctacggcagcaagaccttcatcaaccacacccagggcatccccgacttcttcaagcagtccttccctgagggcttcacatgggagagagtcaccacatacgaagacgggggcgtgctgaccgctacccaggacaccagcctccaggacggctgcctcatctacaacgtcaagatcagaggggtgaacttcacatccaacggccctgtgatgcagaagaaaacactcggctgggaggccttcaccgagacgctgtaccccgctgacggcggcctggaaggcagaaacgacatggccctgaagctcgtgggcgggagccatctgatcgcaaacatcaagaccacatatagatccaagaaacccgctaagaacctcaagatgcctggcgtctactatgtggactacagactggaaagaatcaaggaggccaacaacgagacctacgtcgagcagcacgaggtggcagtggccagatactgcgacctccctagcaaactggggcacaagcttaattaagatccttgacttgcggccgcaactcccacctgcaacatgcgtgactgactgaggccgcgactctagagtcgacctgcatctaggcgccggaattagatctctcgaggttaacgaattctaccgggtaggggaggcgcttttcccaaggcagtctggagcatgcgctttagcagccccgctgggcacttggcgctacacaagtggcctctggcctcgcacacattccacatccaccggtaggcgccaaccggctccgttctttggtggccccttcgcgccaccttctactcctcccctagtcaggaagttcccccccgccccgcagctcgcgtcgtgcaggacgtgacaaatggaagtagcacgtctcactagtctcgtgcagatggacagcaccgctgagcaatggaagcgggtaggcctttggggcagcggccaatagcagctttgctccttcgctttctgggctcagaggctgggaaggggtgggtccgggggcgggctcaggggcgggctcaggggcggggcgggcgcccgaaggtcctccggaggcccggcattctgcacgcttcaaaagcgcacgtctgccgcgctgttctcctcttcctcatctccgggcctttcgacctgcagcccaagcttaccatggtgagcaagggcgaggaggataacatggccatcatcaaggagttcatgcgcttcaaggtgcacatggagggctccgtgaacggccacgagttcgagatcgagggcgagggcgagggccgcccctacgagggcacccagaccgccaagctgaaggtgaccaagggtggccccctgcccttcgcctgggacatcctgtcccctcagttcatgtacggctccaaggcctacgtgaagcaccccgccgacatccccgactacttgaagctgtccttccccgagggcttcaagtgggagcgcgtgatgaacttcgaggacggcggcgtggtgaccgtgacccaggactcctccctgcaggacggcgagttcatctacaaggtgaagctgcgcggcaccaacttcccctccgacggccccgtaatgcagaagaagaccatgggctgggaggcctcctccgagcggatgtaccccgaggacggcgccctgaagggcgagatcaagcagaggctgaagctgaaggacggcggccactacgacgctgaggtcaagaccacctacaaggccaagaagcccgtgcagctgcccggcgcctacaacgtcaacatcaagttggacatcacctcccacaacgaggactacaccatcgtggaacagtacgaacgcgccgagggccgccactccaccggcggcatggacgagctgtacaagtaaagcggccgcgactctagagtcgacctgcaggcatgcaagcttgcaggcatgcaagcttgatatcaagcttatcgataatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaaatcatcgtcctttccttggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtcttcgccttcgccctcagacgagtcggatctccctttgggccgcctccccgcatcgataccgtcgacctcgagggaattaattcgagctcggtacctttaagaccaatgacttacaaggcagctgtagatcttagccactttttaaaagaaaaggggggactggaagggctaattcactcccaacgaagacaagatctgctttttgcttgtactgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagcatctagaattaattccgtgtattctatagtgtcacctaaatcgtatgtgtatgatacataaggttatgtattaattgtagccgcgttctaacgacaatatgtacaagcctaattgtgtagcatctggcttactgaagcagaccctatcatctctctcgtaaactgccgtcagagtcggtttggttggacgaaccttctgagtttctggtaacgccgtcccgcacccggaaatggtcagcgaaccaatcagcagggtcatcgctagccagatcctctacgccggacgcatcgtggccggcatcaccggcgccacaggtgcggttgctggcgcctatatcgccgacatcaccgatggggaagatcgggctcgccacttcgggctcatgagcgcttgtttcggcgtgggtatggtggcaggccccgtggccgggggactgttgggcgccatctccttgcatgcaccattccttgcggcggcggtgctcaacggcctcaacctactactgggctgcttcctaatgcaggagtcgcataagggagagcgtcgaatggtgcactctcagtacaatctgctctgatgccgcatagttaagccagccccgacacccgccaacacccgctgacgcgccctgacgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgtctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacgcgcgagacgaaagggcctcgtgatacgcctatttttataggttaatgtcatgataataatggtttcttagacgtcaggtggcacttttcggggaaatgtgcgcggaacccctatttgtttatttttctaaatacattcaaatatgtatccgctcatgagacaataaccctgataaatgcttcaataatattgaaaaaggaagagtatgagtattcaacatttccgtgtcgcccttattcccttttttgcggcattttgccttcctgtttttgctcacccagaaacgctggtgaaagtaaaagatgctgaagatcagttgggtgcacgagtgggttacatcgaactggatctcaacagcggtaagatccttgagagttttcgccccgaagaacgttttccaatgatgagcacttttaaagttctgctatgtggcgcggtattatcccgtattgacgccgggcaagagcaactcggtcgccgcatacactattctcagaatgacttggttgagtactcaccagtcacagaaaagcatcttacggatggcatgacagtaagagaattatgcagtgctgccataaccatgagtgataacactgcggccaacttacttctgacaacgatcggaggaccgaaggagctaaccgcttttttgcacaacatgggggatcatgtaactcgccttgatcgttgggaaccggagctgaatgaagccataccaaacgacgagcgtgacaccacgatgcctgtagcaatggcaacaacgttgcgcaaactattaactggcgaactacttactctagcttcccggcaacaattaatagactggatggaggcggataaagttgcaggaccacttctgcgctcggcccttccggctggctggtttattgctgataaatctggagccggtgagcgtgggtctcgcggtatcattgcagcactggggccagatggtaagccctcccgtatcgtagttatctacacgacggggagtcaggcaactatggatgaacgaaatagacagatcgctgagataggtgcctcactgattaagcattggtaactgtcagaccaagtttactcatatatactttagattgatttaaaacttcatttttaatttaaaaggatctaggtgaagatcctttttgataatctcatgaccaaaatcccttaacgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaaggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaaacaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagagctaccaactctttttccgaaggtaactggcttcagcagagcgcagataccaaatactgttcttctagtgtagccgtagttaggccaccacttcaagaactctgtagcaccgcctacatacctcgctctgctaatcctgttaccagtggctgctgccagtggcgataagtcgtgtcttaccgggttggactcaagacgatagttaccggataaggcgcagcggtcgggctgaacggggggttcgtgcacacagcccagcttggagcgaacgacctacaccgaactgagatacctacagcgtgagctatgagaaagcgccacgcttcccgaagggagaaaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgcacgagggagcttccagggggaaacgcctggtatctttatagtcctgtcgggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtcaggggggcggagcctatggaaaaacgccagcaacgcggcctttttacggttcctggccttttgctggccttttgctcacatgttctttcctgcgttatcccctgattctgtggataaccgtattaccgcctttgagtgagctgataccgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgaggaagcggaagagcgcccaatacgcaaaccgcctctccccgcgcgttggccgattcattaatgcagctgtggaatgtgtgtcagttagggtgtggaaagtccccaggctccccagcaggcagaagtatgcaaagcatgcatctcaattagtcagcaaccaggtgtggaaagtccccaggctccccagcaggcagaagtatgcaaagcatgcatctcaattagtcagcaaccatagtcccgcccctaactccgcccatcccgcccctaactccgcccagttccgcccattctccgccccatggctgactaattttttttatttatgcagaggccgaggccgcctcggcctctgagctattccagaagtagtgaggaggcttttttggaggcctaggcttttgcaaaaagcttggacacaagacaggcttgcgagatatgtttgagaataccactttatcccgcgtcagggagaggcagtgcgtaaaaagacgcggactcatgtgaaatactggtttttagtgcgccagatctctataatctcgcgcaacctattttcccctcgaacactttttaagccgtagataaacaggctgggacacttcacatgagcgaaaaatacatcgtcacctgggacatgttgcagatccatgcacgtaaactcgcaagccgactgatgccttctgaacaatggaaaggcattattgccgtaagccgtggcggtctgtaccgggtgcgttactggcgcgtgaactgggtattcgtcatgtcgataccgtttgtatttccagctacgatcacgacaaccagcgcgagcttaaagtgctgaaacgcgcagaaggcgatggcgaaggcttcatcgttattgatgacctggtggataccggtggtactgcggttgcgattcgtgaaatgtatccaaaagcgcactttgtcaccatcttcgcaaaaccggctggtcgtccgctggttgatgactatgttgttgatatcccgcaagatacctggattgaacagccgtgggatatgggcgtcgtattcgtcccgccaatctccggtcgctaatcttttcaacgcctggcactgc  Z   6   :      9   B   7   '   ,   &      $      =   3   5   >   >   4   #   ?   ?   7   #   3   "   -      3   "   0   %   +   =   +   "             '      $      '         #         2          /   C   0   ,   -   H   &   =   '   (   ,   >   ,   7   /      @   6   D   6   -   *   !   !      )   A   ;   !   :   F      ;   8   K   1   +   #   )   6      '   )   1   /   +   &      "      5      !   #   )   &   '      ,   ,   .      #         (   9   +       8      )   $   )   6   /   #   8   D   -   2   0   ,   *   (   5   %   &         6   :   !      &   &          .   +   !         -         +   !   "   &   $   (   1      3   !      1   1   X   '      ,   '   ,            #   ,   0   (       6         )   "      4   5             8   ,   %      !   %         &       "   (   >   4   =       5   A   /       1   ,         9      (   +   5   M   9   4   7            ,   +      <   <      )   /   8   %   '       8   /   (      /   ;      =   ;   1   "   1   0        6 ²ÜÞN¤¥ÐÑ1t|ÿ‚ƒ„‹Œ�š[\£àr™ÒÝÞêöû|ä:;<�ÚÛ_� ž ·!ä!$$$Á$Â$%%%: !TÑßêüXlü¦¹ÒþA	
„
¢
uåÓ …›ø¹A×'sÍ0™/œGé=–ª�ÜEÚ`Ÿ º å!|$¶$Ã$£'!(F(Ë)  ³Ý9‹š
}Žì¤m�Ó×w*ÁDP�!æ#$ž$â$(&©(Á(9  ryÖøOõ·
2Nd‹ Á6]#á§šÀßãëï÷ü W€¼ÝãéøŽ*]}åòÆG™§å'¨Ï¸!$%Ò)B 8 "-bvªëYv�§ÿ




L
‹
£
²à•%'=Si|‘ºéFaBØ(•t�†ž¹š05—9FÛw ‚ Á E!Ž!æ!6$}$©$·$%E'Q'¤'7 †-= !½umßºÓ°	Å	…
¬
V‡¦ÂÍ@Zœ‰K!R‡Îü¿êC«‘amË» £$Ä$"%Ñ%×%&.&v&‚(' ë fyÈÑ¤ôUY]	š	evÜÔL†0‰A“Ó<º_"   A!K!ö!p"Ò"(# $€%<)¼)Ì), ¤©Òàýý)B	
æùmr�}Es1¯ÊÙN{Øí)�ßHp>çGÝz X!ë#‡$l'½'"(G(& L–*øZŒl
"¶¸¥¹ùÔw°»îVhÇTR&E”!"w"#)&q&ª(9)C) ½ Ð ÅšºÏ
è
x�V�nÞŽ¯ûøüÂl¹¦!Á!+"F#Œ$“$Î$Â(F)$  ´ú^£yCÅ›
~`¡í\"x�kÞãmí-BQþz!#ç#$ã$@%Ï'N)–) Þ:»Ø“x+Þž!$Ÿ$Ÿ(‹)î)=   œ ñ \îù	ðIPS¸
­ŒÂ^ú$oEw¯âàìøý�Þä³¶ÝR^¾!Q¼_t¼æ	´!H!Ñ#$„$%œ(µ())Ó)3 M ö _>nBö]
3DOÏce’¡õ¼â…¨›ùû$YiI~óVÊ¸UÿÐ& ú /!í!š$F&Ž&©'‡(*5 ; Sjzµc/y0	Pr˜â7…ÓìÁÉäð½M�+næë$‹H¡«š¨(©r!v!M#Ä#$:&‚&ý&H'Z'x'(")‡)> ³ s×#˜óË	ì	ð	Õ
½Å¸Ûý˜Â'½Äü’¡X’ÉêU3‚¥?=a€“ÇRÎÖ^ i!¹!ƒ#5%G%R% &' ')'T'> 9 ;hø!wìGLwÃ	


–ý»b‰ž¿4¡Ù–·%ZuÇ„‡ºÛáçöŒ­1Ll‘ë3çëx F!´$Ï%''C'F'R'§'4 ´”Ú.0ceg�Â‚„†‘¨Ÿ	

c
r
t
ë&(*,2êG¯CEå¢Õa G	¢x3 "Ü"N$e$~$ª$'Š'¥'# nÇtr«‘]M
h
³áÉG4ŸÏàL6µÏÙô:ÏÕLz O ç!¥"–%Ã%? V %#JŸÄRZ“ 	É	}
Œ
¤
(>Tj}’Ë7;)®Ž€z›=-õ�˜¯IÜ›Õƒ Â Ý �!—!µ"/#W#7$^$¬$¸$÷$%š%º%Ë%Û%0'/(û(? ƒP‘žvŒi7~-	c	±	Æ	 
e
­

U�UÆ"SˆÏ^|ñ!Zrx«DZ³’Ì9‡ Ë z"C#y$Ò%Ø%J&’&;'))7 Z { >S–"'Là	»ÔØ$	v
Wˆí)}�É
SŠ£5 bÅ) þ!Æ"g$€$Å$#%/&w&Ç'3(ƒ(	)[)# .¶¾39ª%
†
I§Î.8A[¨Ä¡Ç!±ŽLcë3Põ5 Ç &Œ'3 /‡Þ!É2¶n÷	f	C
ù
Ã2H6LbxŠ ØI¨_Å¦ýÀ¬ënZŠ¼ !ú!‘#$;$I$¤$²%({(¼(Á)" º æ ");beÆõVZˆ¶ÝÀhp£BŒn3˜# ë B!¾!÷!%q()1)š)- GÒ”ã¾›	¡	¿	
[GŽÕÇŠv…ÔØb9°S L!…!"‡"^#Ô#ö#$P$�%Ÿ%�'(Ñ(=)©)µ)Í) Ú >Og¶ï0Á
	wÈA‡@”§= "P"T"þ$x%&T)½)3 ì zÜÉ�¥MÄ°^	m	÷	f8Má1œ2LóR×c» b‹:•<`qs ¡ ³ "q"}"Ë"Ó"Þ")#ß'S(é(" ƒ 8#Æ
Ì
SìX‚ç÷F°ÚO|‹*iI²èH›¥KÉÚ á!ó#¸'0 G ›¥�~7	C	Y	¨	º	
Ú
ç.4©¸ú&nÚsKt2kÙàù]Šƒ‡Æ¤+ m ã "ˆ$m't'#(H(ï(% tªÕÓáþ´þ*Vo¤~…ú!-tËîE«ž?òÞù=!ì#ò$'¾'m(�)+ ü ¡í]HÍÚ	ÿ	×ë ©ýfA¤Ï9`¾Ä$™Qqá†¹Ð{ Y!6"’"½"?$¶%4)= é Zp”(+¡¢t–ñÝîj
‚
TãXv#·k¹!{ºÀ»úÕ—¹úÑ;OTP¿ÈÔSN²›!#Â#Ï#~%&,&t&š(:)D)É)+  M�™`.H²[#
ÂFÖ¦¾IxÃ\¡¼Âï¡ðÎ'Q á •!x"£"\$%˜%É%A'Å'º(Y)" —ÙâýÑv–lŸ¡°ÛŽ	°W`0Ýßî>J\ åæt#Ü#&&*&r&  « Îù“£��	m
î
Ÿ•a@k±²YÑáiUgF? "$$­'×'«() ›;õoœ4	~	7
O
’ž¦oßV�Úz¢ò Ó!Ã"v#|#˜#>'( - ¾ ÆØ.­»Ö	:
µ8ùËý-m/ § Â!,"ð"G#”$±'^(“(' 1 Ñ ÛÿÉ¸R›ñé
yWg°êþ@X^qÃ–Ñ×ºÄ§!Î!�$Ï$ˆ%M&•&Ã(Û(`)Ù) 3˜a­4_Ð
¶�²[íIE2ür’` ¤(G)$  =@žr­ ¯-Õ¾#8Byï2ëänâAÿ· !R!è#ý%M(O)—)£)¦)  äGµC_X>nDÆ	 	Ë©]‚ly.RÖ!#»#ú#n%$&¯(+)' & ùFÀÓZûK¤zTa¢­åî	Ñûbßö·îCz|Ž{!<"§"#!#ä$†'Ð'×(  b “
œ
ò%B¡ÑCâ‚¨­"k# $A%b%æ& ° :PfŽ¼«6=N
·ÞÛ<MèßÙ#$ $ß$û$Î(Œ)Ö)ï)# Éß×—À
ÝI—”ÊEŽLÕ,ç÷4N é!2"¹"%Å% &f&®&Ÿ'?(É(s) â xÄ;©ä
-r‰]f6)Ÿyç®ÔŸ!Þ# ( Š ¨/E[qƒ™*Ù:‚LYÚ$3&{&»&�)ß)2  ô ]úQt¢ê	Ãû%ÿ‹Ÿáíùþ´ù?€"=½En~‘k
kýj·\ I!¤!#$…$˜$%3%Õ%»'�(L)  X '
JT�´9�Í+‚ßåÞ_C!Ò#9$Á%Í%}'1(ù())R)  ï•¾
®_p;Ÿ·R�€½Kß ™!·"î"Z$ù$l%û%�'¯'­(¸(Ô)/ � ò ñ:<¹
Fx”°ã0=§�÷S¿
C`u±çžiµ!c!ì"Y#$k$®$¼%Ý%ù%Ù'î'¶(÷()j)C ­ %RÆ#ë&û	o

¦
©
»
ð
ó
ö
;Ðd—þÈö'Ã°½†œ4Bmœ©eÖi´Vf)¶'Ë6< U!¯!T#[#	$›$¬%¾%&C&G&‹&�&'ª'P()0 N `7kC÷�	Ë	æ	^
#E%P²“ù6Ù‚|^nJlÑ×õ û !0!î!þ".%è%Q&j&™&²&a'ð'f()±), ? Ö ÷ ?oqˆ–PŠ¤’	4>�%ZjÓ,¥KWô?t¹á å ' &"V&Z&ž&¢&ˆ(- Ÿ 
>á	R
°
”*@Vl”Of�¢³ã©ÊYx#2³úaü[ô
øWVH�” ²!›#&$°$Z(l)*H < qÎ¡»Û&41	ô	É
Qœs³ø=Xc†Ôêô¤}Ê?
ô,ouŽ·/Ù&fÙÜì%…q)˜ËÞ#6A Ä s!w!‚!"÷"Å#È#$O%œ%&þ&()ˆ)“)& † Tk»ï|Ü{¶ûÊdz	G		«ãjZ²ÌñTI¢2­… #1#²#`$2'ä(ò)= m ‘ æê¡U:Æ)wˆ•0´	Ž
 ™ê8éz–¬¹'n©�br~Ü÷¥gnµÆÓ¬³,ª¿·Œ (!ú"N#2$r$º$I'['h'y'ý(#)' ¾K‹\>n‚Íí7±Âåñ¾NÁ’ç(Œ÷š›©i²œe!­#
%Z%¥%;&ƒ&( Ž ,‚í	ñ	(H:ëh@ÉˆÈ}ÒDS€×qÌâ‘!%#y#©%¯%&'!'(j(�(—(Æ), XçØ$cÌÖ
\ï+™Ãå¢“Êƒ¦„·5'6bŸé~ŽD _ Î º!„#Ë#m$é$*%Û'ä)> § 2ÐL…ô0T}Œ	¡¾åÔz‰Üþk¾Å“Y,V4ÁäÌÐ,�”¥Ë’»Ê˜w ® î " #Ê$%6%H%S%�%ï%$'*'U't(*, ´ t™¥ó—Æ¹Ÿý/hî%U®º>Õb«ãÏ‚ ë‚j!Æ!-$ß%À&Ì&Õ&á&ë&ö&7 ±xÕÛÐékûMÏý
Òþ�™÷cŠŸÀ5¢qÑéõ»Üâè÷�\ãè9F©)D{$�$µ$À$%'&¢'/ …<¨ÿ¼,(€\	™	¯	Ä	
	
K
Š
«
d”Eq€” D…ˆ�®ÉØMzì48Êy � W!o"Ñ"¨$Ð%D' Ä™ùx !·¸[
¯í’jgì,Q"v"E#‹$p&@  : L i=m´"íHxÊ/	\
Ô
C—Î
¬¼‘Ú—&Dv„á‘ÈT2m¤XhHÍG!ì!‚#$ƒ$9&E&�&�&''G'S'Y'w'¨'(†()!)6 ³“sÙ÷ /dfqžÁFƒ…’ž	Â	È	b
g
q
s
|
êÈ')+1 ÊDF 3ÆkKÿØHêÎyÔ2 .#V#«$Ú%'¦'D OR�•�µÝK‹È1hµ}©×	#	,	b	e	
d
u
ø
Hì(-7§| Æ	H°ÅÈ	R^� ª42‰ô 4 Å"�#f$$I&‘&:'‹')6 µÛ“âLÃ‡¯l	 	¾	
ZÇF7à›KgÆòQoÖb¦aŠ9”2;p½!""O"|"Ê"Ý"]#O$€'Þ'(R(´)-  ŽGÌ6	X	§	¹	Ù	þ	Ù
ê-3¨·ë¨üWæ@„£ #˜±\…
¸Å
J£<!"5"¼"ò#s'·'* oØ'_uÍks’žÚí"
i
�
í
âÁE”Õ~¿º–ÐÜIM> P s#Á#Î#—%È%@'¬'Ö')! , 0 ×:n¬›^šð}	Õ	6
9
N
´‘f¥U7Ù_ÐÖ, . L&”&='! % ¿F�q	®S¬Ê¨$ ÐBáÔ7õx@{§Q!Õ!;"¦"~#ù##&å& ‰ ¯ ÈÖ,)H5ˆeM¶Ú; è!Ø#Ù$Ä%2&e&z&­&º&) W &9s”¡é	½
8Šž/œ><m°JiÞ ˜!¶"#X#$8$Y$j$—$­$ø$»%À%Ì%Ô%Ü%0(ö(i)A $jp‡Å‰"êú€	Ê	å	Q
~
¥
¨
¯
ò
õ
:$±ý)?Uk~“Çø&¯²Ø�›Xw�¨{`h(+¤µ&œÖ ô ±!%"S#š#-%B&U&i&Š&�&±&; ½ TÛ9 Å%[‡	F	³	�
=mÿÌ<Wéè6«m	~ót¶.aq}‘ö™ÅÊÝ„ Ã '!0#1$_$¹$›%&1'g'ã(ü(! æK�S|–y*žg­&‘º|—5}�Í �!Å!x#,$%®%(i(–(Å): „Ã˜§þ°»w³+ÏÉ.	˜	®	[
c €D�¶“ƒÐ	~œ®Sì[y£8EiCÉ€ n"Ð"D#$z$‚$…() )F Q�’ŸJŠ�’´EÖd	¦	½	Ç	Ø	a
f
{
GY',6¦{ŸÅûVšÇ?Q]fŒñ"—©¥3[`“Í1:oˆÓ1 {"É"-#�#ñ#Ù%r'¶'³) / ×¾9jšÔ	!
5
R}¹#T•Ó6Ø+¦P!:"×#1&K&y&“&<'); ¼i†Ú !{†8 ù²	è	®
9þÆV•%ç‰.l_}ògs¬;`p|¹Ä–´|É Ì Ä!$"i$–$Ó%T&œ&f'(h(•(h)8 »Ž—ý¯h…I‰*…
Õ—	¥	Ó	4
`
z
Xb+zžÄ‹-:¤27ÃÈ*0¥ O!m"È"Ï"h$�$0&S&x&›&e'µ'„()g)K À Î?‹Œ�#$��	
.ãáfg¼½¾ÙÚÛç¤	Í	Ò	<
=
w
x
y
‰*y~ÎÏÛÜãÊ,š16ÆÇ/ Y"l"–"Ç"####$%%%c'd'³'´'4(5(f)�)1 ÈÏT%‘/dx�äM[âh¿Üâ:	.
>
ºîJm€_ÔÝäN› Sc†�³ˆ!ÿ!—"d#È'6(\)+ P [ f r | Á ¨ç@(¬î(hè%	Î	Š¿ÐË8TÛÍÖ 
!Z" ##Æ$&%ê%(`(
)‚)# ß/8U04[µÃ
¨/K‹`O„á
3Q1?d´•öÈ ÷ &&(])) " ÉÚ&‚¸¿em‚\'‚Ý;	x	/
‡
·©Å¢®¥À�<‡‘§¼¿9! "e#ã%�'É'7(6  Ðõ·’¨9y:N~i«Àã
&
?
Ý
ý
ïö9B\n�sÈÕÞå"íMdœüìðL48vœ6 5!g"a&©&' – Lâåã	J»Ï²�ˆh!T"d‰!Š"˜"ò"µ#è'ç)õ)' 0	I7Mcy‹¡”µŸ`ÆÇèLW‡ÿ ‹p ×  !û! "$<$Ç$'%0%³%)þ)) s {CR)3øé&	Ï	ú
jÄó3ej´ÑJÌ9œ�Íþ‘ÝfV ˜ ý 2!#¥$((|(Â)1  b©èß…F­ÍÕïiÊ·g½g	%‹À©Ü§¸Á¥ûÎ[Ùb © !!!ð!."["7#I#’#J$Æ&Û&a(½(/ Q \ g } £ Â Þ ˆA0"ß)oL	ƒ	D
 ÷ÙqU`èŒn­ìoªI ˆ ½ 	#„%ë%l&´&ò'ò(ƒ)+ » \öRW‰·óµ
ÞLa_?Pq…u�·(' �ÅR@$ › ø C!¿!ô! %û&€()Ð)& E Ø #<l9cf1[
Ä
0Œ5S­¤1`­7 Ó–™÷) M É ø!�"c$-(2)›) ç àÇ¶Â_�yGC¼ÏZo�ã2e”°¥ `%&„'Ã'K(Ì(^)¡)" *0VÌ‰5©MÁi’¥\lâïö4oµ4: ì %&O&X&—& &'X(r( # ÛqËnîœ	À	ˆ
ë
�ª¿Æ£¯I¦Gv*:!""÷#×$¸&5 žÌÝ7AJPƒ¹à,YfƒÓ(ƒàv	¢	,
2
¸Hh}‰¬Ä‹†ÁgA:=¨±½G T M!†!ˆ"Õ#$‚%æ'( Ê'À]•ä¿Þìt	
*
0
{ÖÂGwŽ{’ÀD"F"‚'ª)Î)! CHUêü<	y	\»QÈÕÙcˆçÑ H"_#f#¦#Q$ %ä%Ž'Ê'8(Ò(>)¶)# ù P¡ö¸“:OO‹	
@
á
=]oˆ¨ô�´w�ÂÆ!¬!("Q"�(.)¾)) Û ;Â�¬äq	'
H
Þ
ð÷:C‚ßBÉÖòAîN•í5s¼7 !6!!"Š%	&b&ª&Š(& ?h·Ñò©ÂñzŠ>DTŒjþ
x�Étæ�	$v~àU"a"h"ÿ$''÷'Ý(' 3 ð~)˜1Á	…Ø=iß#)eÐ²ý>ñM9BýŒÙñîy%&ï&5'Å(U)Û) Ó Á±âYâ3Ø÷‚ÆÕU/M}–Wt ´ Ð!	"<((), — MÝãs²¿Êæ‘)	_	n	”	6gÐ2u³�<�–™dÐÜy‰ì¿#Y†ú=¢ ©!Ì"*#ê(, í {[ºž¦Näø	¼NŽ.@SQæ¼!cŒ".§Âìea Š!Ù!r"‹"Ô"ó"Ñ$\&¤&à'é'y)è)ö). A v Æ é—æ¦Å	P	K9mò…Ý±Mô×5ni;»˜r¿~"™"ß"¶#�$q%Ð&˜'T(b)¬) š J@Í
JTz´óYƒ¶øÇK±ÛP}º¦  â!$>%# 9E	Õ¢œS µaÍô‰é+³XˆéJq Ø Û é ß!ü!ô#=$²$´%ç(í( 1”8NdŒ•©G[4ZÈMJWLŒ!¡"\( „ $aÇ
íöè%ŒÊ×j BIœ!Êp$È$(%1%æ%¹')ÿ)( J ±DkùD	Z	{	ã	Ò
*kÅè/5’µõû‚uÿáeÃg , "*$W$‰$¦$u'(Ã)9   ¡ ¦ûbvf�±þÍ8	J	»	Ð	
Û
û
ôü4kq½ÌÒÙo’�å·Lê¡Åæ4˜ú^‹”bÇ¥n – þ 3!#p'}(ð(+ t œ|Sï*ê'	fª¹'KQ]ƒÛ=O¯:EÎÕŽµ3lÎÚe„ŠÞU™ ¤#^%+(:(I(  H öi­¯ÎÐ4A©	ÓútÍµÌòˆ’éW ä Ý!($D$n'($(8 Í cìnW“Î	ê¸ÿ6tW>	™,BXn–†ÊÝ"¬]uö@t²°Ïß$\Y !>!´!"/"²"J#h#K$Ì'n(²(¾(I)* ªé†ÖcËh¾p²
Á¥ævbu†ï¹¦ü!ë!!ñ!'ž))  Ž« Gðj¹¯Ôâÿh	¸xªû«x¨Ÿ*¢XŸúc g !]!J"\"Š#ó$“'(&(n)$ uƒàd®Ö#ƒµ+&Œ	Ï.ÌFÂQóYÚ ª "!@"8#“#í#Ç&Ü&¿'b() ¤ ß 5WÞ	ÚhgâjÛéz¿Û\‰Ñôý| ‰ ¾ #�#ã#ý#F$…%�%¢%·%ì%¦(Ô(@)„)6 Ã øìàªÒ6IM	«	Û	E
X
–!ÜrªLvBrþ%šô‡‡ú
 J Ó æ Z!7"“"
##4#a#‡#¾#m&µ&�'ó(v)/ R ~ ‰­B1š#*î 
^Øðþa¥Ð:
a�ßR�Š8râþOí¨#@$S$ì$ó'B(5)¸)# ] h ý ¢÷þC^pÎ„	T
ìø¤mïVücÅGo®ºŠ”p«¾"8 q SÝ÷8WŠ¸ô@	ƒ
™
¡
¶
0s{äMŠ¸@Ö"ß¦˜¿ÌÖ/˜).{ñÅv•ŽÀä&COœ ¹ œ!¶! (E(À(Ê)Ñ)D 7 ê e£, ÇÐt£óXuÞ

U†¥±ÁÌÛß?Y$è/`l|ˆŒQr†¸×û(’ÒÞ;Bæ^@!D!�!õ!ê#5$!%%&-&u&P'k'�(;)»)- ¼ Ï •)]¢÷B¹Yk
ç
_wœºøvº®!Uw€÷âûÆSA%ýy!À!*"#Í$Î'8)E)Š)•)2 ð R[—òbï	Oqbán»Á®¼Ãû‘<P# ªQsÉÕT³% ù !u!L#Ã#Ð#F%Q%ÿ%ü&›(´()*0 U $m:gÆIQ�\
6®3$y�2�Îó®¡Ôwš N –!"¤"´"Û"M$]$d$ö$•%™%Ê%/'B'‰'.(, z ‚ &286$
B
1ÃG×T§Ä]{¥ðYqw¢²Ä(8Æ Ê ù!y"$Æ'z(»()Z)À)* ¹ Ù å !=NîadÅ/œÀ½ö	�?¿1¢uam8¯—R ² „!"S"†"%w%ž%p(0)™)¨)( F û šsÔì\}³nÅ
Ë
ÿeöù J½Ãªhøñš¤ÏÈø* l â ‘"ñ$ '3)œ)5 ª è €“˜áüÐ• -¡G ¢¯±Ü�	�	SžWu½z Ð:X_/Þàíï[ŸÍäf±%}%&&&+&s&Ä'% Úþ-—¬Èô·Q`33	µ±ZìHD1éq?]py‘¡•¦ ñ u#—#£(Ú(_)&  a ãøEÒY<?BJW=m¬	’
úA½aî1ê¶áy #j#º#a%…'L(¢)¥) w§Ãã
.DZp‚˜9�(D�	K­æ3ç1"Ý#Þ$&Í(r) ŽÌþ“¦öB�jhü[ !b!ë"k%|'®'Ø'¬(K)Q)6 > ¬ 	6Q•O£‘	n
ï
"“–N€Â=Al"d²Õ³U]emZó÷5VàG; “ T!®!ý"%$&P&Y&˜&¡&'`'O(Y(: JpºÍåéî{ŠúºÉ(v”3�›ª²b°ÀÛðö%eÛ'S„fm´Òp+h±¶5¬@ �!ö"ù"±#Ç#	%N%Y%)! +1WÏ/‹¤ ˆj9$¹ãƒ¶ÏÔ4‡ÉâÑpC í "$#Ê#s(�( <jJ
‰
“ŸÍ«Cpà�¨+"u"�#&&X'& œÜrØöpFÀ|®	"	5	k	�	¸	Á	EÇ§J2PJ„þ1I;!"N"Ä"(& $ ˆ ^ÖÌœmp�Õï8
ì
­�«ÀD¤§ÔdÛHwÔ!r#}#ø#Ø$d&¬&¹&?'Õ' ŸoÄˆér	P
°è×šW§%'{£4ó &!w#™#  . ÂÖ½8º zŸÈ×	¥ÅC\ð¸hB{n0 Ã!#"Ö#$•$(”(. q ¿ ºÇÍæ®-g„'HZ)„áæ£	-
3
;
a¹I~xÃ90ÂRÌ…².¤N!‡!X"k"²'(_( )+ • ŸÞô7ÙK�§·áZ}	w	¶Š­ì‡àïK7u›20;>¾8!f"‰"ñ"´#&'ç'ô)!  Ý /BQ„EÔÞf¼òdi_Œ·¤ú†þ©H U ‡ ¨ !-"Ÿ"H#ƒ%Å&Ú& kˆ^ò
´
x»Îÿ0Y_n�Ä“Ò¯9 ó!b$%N&–&'ƒ' )Ï) BËÜ6IÊXßís	u	)
+
1
ê
z|¾ÁÃHFz)E"G"Ö$å'- 2  ñ(~ÁN=SœŠ	à
<„×hñ±ó³Ar#u}ÁØð»Åí!~!‰%'4'ö'Œ(Ä(Ü(-)Ú) Ò ¹¾–åÀáXx�ë¾|—¾¨!Ï!Ø!Ž$Ð$p%—'a)«) DI`³›òR¨óJYˆÉÖVA =%å%æ(+  °õaeÍý@ÌI	z	Ñ
ù‘¼ËØô\‘�´é Äñ3—d“aÂ‰TèÜ!£#C$V$9(! �ëm‚Vcÿ"b¸®5=	·åuÉws¯ # f !!!?"I"g#Ë'±(H)" 4V¬™ëý©]lîiqFÚýÒ #3#`#§#½#â#ü#R$Œ%¡%�'¥(Ó(?)·)& Q¢sò
˜
 
z¤°Ë>^p›‰.­÷—Özð"ÄáåãBü¸ )"é#4$þ%O'j'$ ¸ ú ÅÄÓ›|�mA
þøzt©ÍÃvÇ  ± R"…"Ú"õ$”%ˆ'/)˜)§)¿)(  ÷û”«ó;>AIŸ¦PV<®Œ	‘
â
VŸè9Cpìxžµ¬x#%Ù(q)¤)1 I¹äèíPÈ.Š2 !€’±ý¯d¿õ$d‚µÓ3lÈoòû’ !S!€!­!ü"##M%X%_'{'N(Ž(P) ÕžlÃoEÔ­!	j	·	I
DÌCªÓO™$ƒHM"€#%&c&«&Ô'3  p ” Ü ¹Õå6€¦¶DGYyžÇå	ñc¤wBëï^¶ßî/·6tz/£!7!""W"e"j"ž"
&(ÿ(! Aj5HMW½<r	(
ß
;ƒàð€/m(|ï½8 }!×!Õ$o%''–'‹(,)  Œôbþ`!?øÊ×óp–È®ÁS e  !>"¼#á#û#<%‹%°(1 ~úHÄìªÃò¥Uñ{-l�
ÿ
y‘ÊU°
ýö–®žçcÃkàwú‘ „"#"#%L%W%“%N'^'‡'Ø(p)1  o “ @i¸Ô5Ôó4�¥ýL FÓ¶	b£vïÒ˜ÇÞ..'{¢|!="L"V"d"i"Ô$;%''•'Ó'
(X   ÒÓGÁÂÃ[\]£¤ü‹Œ�Ž?E+,Òk®¯uçü|Æ
,-ijï%&Z€÷øù}�¡Ž � � b"c"‚"ƒ"¨"ã"ä"å"æ"<#=# %%9%:%K%V%''	'
''K'L'M']'Ñ'Ò'ø'(	(ù)' ' ­^{�@�Öäºæè}»\—¡§÷¸ðD[�á~�©"ç">#å$f%ù'Þ(ú) Â	>é$*Ñ×¶]Ò)ª¢^¢¨ò¤¹\ª"!$æ$Æ(V)|)Ü),  c ²|�A€Ž±—U	û	†Ùçjàz":¬ß)¢«D’ãNÕñ�¹Ú^"P#Œ#&((%)û)' 	 4 �ñ*_™�
»fó¼C³?PCƒðøE‚©ïi _!×"è"l#o#c%z%ð&w(, ( 	®ò2»×å”
ì.~Ñ&K†ù˜¨þuy™:þ.âò
‘*!n!®"?#t$¼$B%g%ç&6'ú'ß( ± -Ãê%;Qg�Ñé_¸ùÜ—¥º]Üu g!$¡$à$'' � Â!?Q$½Ø¬7X^ÓÙ«OƒÖßåóNXü$ (Ï( ãÏ+>iøVÉNµ Ñ!«"Ú#"$%=(Ç())W)�)×)Ý)# Ô ²	ZãÒ4È9·*£Ç*£©0~�=é€à¬ ¢!
"«#ç$§%ì'd(})ð),  M³äàÊØ˜*	V	`	ü	èÞžÄçó@F�¯Ö$]èO>òê!3"º"Q#%Æ%!&g&¯& '0 d y�³ËØ²€˜•	Á
7há{´#˜=d‘*š¬“e•ËÑzŠf¾ÖŽºÛdÍ"+#�#ï#_&§&ü)( ÊNÞ°ÀçB�o	Ž‡k3ŒO—£EäíÄÀ-«ø5ž£ ª!B"_"Ž"&Á'Ê(&)  ˜ Ë t}‘�’(ÑÚv;J­à`ÝOMZ‡òû  "\%)(@(ë(t)6 5 ã î ‘+yÅ6Ÿ@O`ª·å
.„¿/ŠÁ½ 7�@QŽd~�žèõ¨ñùfk¯ªj `!‹!é"ô"•#¯#ï${%-'x(¡( Àò\€š%§çˆ	¼ð�s0AgçH%/D„?ƒ$!Ú!s"p#ã' 
 |â`»ù	ž
 ôI´,— "F Õ"Ø":#m#ß#Ò$d%z)÷)) w<>^å½O"ÊTV^gDR*½z|œ#ÃÅÇí[Õbð !Œ"ò%]&¥&ñ&á'ê'é)" ‹ §Ø3I_u‡�†ïÚTÀ
:™ÿš;¼×™ão!@#�$É&Þ&è&ó&�)ë) ) B 
ˆf©çæ@:nó}²NÒØPj’¯"½$7'U(à(c)4 w 	…¯3˜	•
Lp0F\r„šÞí+õ³FL6ƒÎ7Ã”Mv<ïÿ/s"à"·#Û$C%h%5 Ç êó…¼ÆQ	óÌ/Ó
';o‡Ñâú©¯Zz¿ÎS´óÀ+!Ê!š"u$r%ô%4&=&|&…&¼&Ñ&™'û'­)à)     û£ëZ&lŒÜâîúÿV›F˜¦Ù§Ù^Îã!å#$$á$¨( xa©uK&<Rh{�J@¾o¹Fl! v À J!'#ÿ#†$¢$%Ö%¼' KÄÎ
UµÝúÝlk¸Ý“!¥!#$’$?%ž(B)M)í)8 › ² õ ^.ARë	ï	Äô„·Òùü ë ÈL²µÜúQ~�½ #>»ê`Š’U^»·þ] .!h!q!™$4%('†), œÃK�ü:ˆ�¾ä¡­¶YƒÎÔÚàæõ‹¬ß<K`ê,´æôKÜ ³$¹%Â%Î%'~'ú(% Y .ö 5Kaw‰ŸŽTbYêOÿY†~ !ý!B#:$H$x$±%(2() (:Fµ		@„×‹r ê Ó#õ#ý$&Ð(è()S)! ‚ 7"UÖR£%ÙÎ,8_jsŠDPà‰‚†Ù à!>$µ%l(î(% Y•ð¯j` ?HjÂ[ ¸Á±ùNS=O¾Óåà š!¢"Û##$[$™(¹(X)È) 2ýWÊÃÍ!Ò!Â"ï"{#‡%°'(](’(Ø)  äÐ,ñA��¶ !¬"m%ü%®(Ö(*)& á ¨–¿
9Oe�Ü–qª<\5ÉKXžÝæÔLÓöM¸"ú$%ž'>(È(Ž)Õ)Þ)  ó ;³*:<žø	BD}œ�j¶£!í"2%ø%ú%œ'º'í'·(ø()" ž Õ %=	à	º
5É31kÒ	J>sä!Z#$¯$«%½%ç%ï'e()k)~)°)( l … � Úó	È
÷iéóYy•£±|¸&>¨�ËØ¤Ø1²—¾›"‹ d!"#¬#q$¤%’)ñ)> � ¦ „òb[äîÓGä.í+gTÀÈË+¤ªÊCavžè�Ÿê�Ëá­ Ÿ#l$É$è$)%�%¨%Þ%î%¿&Ë&Ô&à&ê&õ&#'Ú'ã) *4  K lÔÚèú'Îü[	ª
Ó
BÑ	˜öpCèôÈ×WgGâ(fÌ7PV!ë!Š$œ$§$¿$%8&D&o&€&Œ&v'¡'(= ²N´ÇáKË+	W	a	ý	p
Ø
÷
Æéé06¶ÿÉß§ŸÄƒÅnÅÿj°‰	·×8Äéó ¼!"4"»"U#\#H&�&'9'Ý'Q()  + ® &E
Ùì™	|	€
+e“(¾‡A ^? - = À#Í#Ç%"&ä&«'5 åS8€$E	ä	§
¼
ñ
ô
<l#ü÷x±�5v�ªfµ�l*%€h°!#R#
$+$0$X$,%­%¿%&A&h&‰&°&â(õ(Ä)A ¦Ù‘²ÿ³Î™Dø­	¼	ç	Z
8Fý&5Q|”µú$™>Pe’æ‚¸k}›­R”ëf–¢¨Ò5_o{_×•ÈÒ9",#Ž#ð#q'g(²)/ O e §ŠüŽcw€«âígˆe9	–	Ì	Ñ	_
l^¾ÍÓÚâ7ÚM+™�Õ 	!•"Î"ÿ"#c#é%R&š&b'e)€)  ! 8l´&�
Â
Ü
ü
õrƒ¤ûg	¿Œ!c¦»”ö 4!â%`&¨&~(æ)1 ¢ azÌK	‚	$iö³p“´›žç ÆÌç‹KmV�ÜeØa o — ü ÿ 1!ï!6#/%k&³&ñ'ñ(ý), D × ËÁQ€4LR^¬>‘t�¤¶F'&[kî¬õâ6Ÿ( L š ¤ �"_%W&Ÿ&ú&Â',(J(W(Ë( �@OTpßé+ûëgˆ«ºPFf@uæF Ð C"¥#·& ø }ð‰—C‹p	G
�Þ<(Ï€ü‹ß«!'"`"&î&‰(9 @ u Å Zr±è�¥(	O	“	5lñt„Ü�°-;?ÖP•˜4måÏÛöÅÔ-¦Á.LX…ëºùV [&£&Ï&;(')x) ™  “?Ôõ´Z$3Ì¹Iè Þ!o$±$[(ì(( I   úhjîu~¬®°Ïâ	)ÒûpP‚
<N®Dä¶ËÍÔ´åd • '$)$]%o'*(+ Ì ’‚és±
˜+AWm•wÎªa…\tõ)P±¡XWžêX \!³!"±"‰#’'(%(m)*5 ÷öÑ5Bª	Ý	S
W
•Ûïg£KuáÚ	yûbýœÞó†‰7N[ˆù‰“óü	 å #†#œ#E$ë$A(u)M 6 Î ï dÆÏÜö 7AVa¸X	?	
æ
/Nr…ÀÚçàÕ m‡Þ‹¥Â¾Ë.-‘­ vÝ:Au”Ÿö©úr%$]!?!t!x!Œ!µ!K#Ì$E%P%Í'(D(³(¿(7)‰)”)º)*9 T y ä ír%7¿ë¼P5õ	Ê
>2dõ0#~Xpv�g÷Ž±òl™£®7k Å ƒ!""³"$L$ð$v%�%ÿ&.'o(y()4 ` © ’DÏ,X, F2«	2	R�t´-CYo—ùY¼ë@8€0'^Œí.éàÌð 0"i#–#¹#Ý$|%&¢(7 = oz”
N¢¹'uš‡Ë<!8c#Ôõ¸TÚÎÚ&ARƒ†�e³Ð*g°ß«B Z a!ê"õ"ø"°#Æ#É#j%J)	* ‡ ]×›‡i¿èq{	¬¦çÖ1BcI§ý&03%!t"q#W' Áó¼Ý&|e`Â[J£Q…š1„† ³#Ä&Ù&'ó) ð}‡‰	³

½ÀwºÍò²E½y"t®ì!ò!a$%3'ä'õ'Ÿ), U«¯êl�d¨·ÌüËH	šäñk�t€§h³òXvè‡ŸÃðU@"!Û!#2#¢#B$U$å(+ · ãçÒHš;Ç‰Ž 1—
Ÿ
£š÷ü¬ycsÒ!oÇÌ´ñ«uû° Ù"û"3$ô$i'z' ‹aV¼kxi	êoµ#¶­ÀGî d !�"à#þ(<  n ’ }4¬ë3œ¢ðÕã*Ñµ	�
¹{—õ•­º[ÅÝæ-– ¦Â +hYö � K"�"â";#Ó$8%J%U%e%’%J'\'”'(o)ø)<  �±ñº°–T	ú	yÐÖë !-9«Þµ(Jª(…‘©øO]tx˜¡§Ôï£-¸	h )!^!m!]"Ö"O#n#‹#s$»$'(v($){) €  ,PÎ#ÐWÇ8hè)äøÈœÛ« f!¡!ª#%¦%&'ë'ÿ'c() Ê LxŒ¯×É'�‹c_ÃæòN?Ãe®½ª\�cñ "A"�"î#[%^&¦&À'/ ¿vá$5=?]_¶æ‡	ƒ¾!Éï/UÀHG�+�–{}›�ô$ÄÆ>Zj#!9#”#®#î$ñ%,'â'8 „‡e„?o
ò2H^t†œË|Ò	î²ES¿OÍÐ	69áÂ“®¾ÍRî³ÖÉ!ó%<&„&È&Ý&ò&ê)% w`¨î	IkÜêÛU¼š‰ET]Ø¶ØÍ¿ -!p!’!&#ä#þ#‘$§(A)…)ì)' -6›õû4J`vˆž‡ãirŠ;J�Š…þ…} A#G$w$°%¸%&'k(  à X§ÛiðÁÀ°ü@ Üå<ÓÒÒõäÂÌ!Á"z#†%(‘(˜(Õ(Ç)8 k Œ � ¥ ƒÙß	ò	hòX)¢-2{;ìfAÊ×|›ÉÑ~rŒ–½šãŠ #ž#Ž%£%ª%í%÷%¾&Ê&Ó&ß&é&ô&"'›'‘)¯)â)/ * ÓÙ	7çJÍ×
A"¦ow~ÄþÇkˆ7 »!#¿#Ì#/$¾$+%7&@&n&&ˆ&ã&8'Ü'á(ô(( ‰¥ªáì‡%d¬	Y
õ]³Oš�æ£jQÿ§U �“` Ô 8"”"5#b#á%d)å) C Ä YèúN	F
Ý;ðs«,s”&õêûE K Ï ¶&Î&í&ù&V(w)/ ÿ ùgíõ«èrÜ	V
—îoô	MCÓÙË„›äs…ˆ¸6(°c ç [!°"#…#ˆ#n$ê$‘'; S _ x ¨ C$+¾EMõ1U		
MqÙæß1»ÿl;b"-7ÓWS‹Í-9‚“¢­ï ¸#Ë$Ü$D%i%u%C(6)¹)* ® †_¿™¦ÕñWžÂ±P™¼x0!s¡#A$T$%Ã&Ø&V'ô'= ¶ Š3°2›Ñ™ï�ÐS	–
¢ÏÕÿ,Ýö ”´Z'„Äå•Ñ N\sw¦ÁÿËîð íõt¯ l!€"œ"á"7%I%T%‘%u(;  É 
†4~È†	ñ1G]s…› Èî{ŠbÑ¿ÆGM>Ï58àŽ­d•­Ìã¼=È!"©#í$ð%%'+'þ'1 j v_š¦ôúñW¡,1eq‰I¯»û?Ö{ÐäÑ„‹•µ„Á,!Ë!À"v$ö%½&Ò&š'®)á)" þ ¤ëôù†qU
íô¥n€iýÆãrT¯.$à%6&?&~&‡&Í&â&ì&ø&1 ^ µ È ÿ½DÇÏR	…	˜ÇÎ0ºÔÿð!&=ÒV¬°[c¬À»¡r¬ìôk!Ç!›"t%Â&×&ý'0 i u£øùÍð þ()*+0ï <dpˆHpqª«ÏÐƒqƒ¿"s%õ%5&>&}&†&Á&Ö&÷&ü'  9  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                        3                                                                                                                                                                                                                                                                                                           0                                                      
   	                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         	                                                                                   	                                     (                           0                  
                           	                   #                         3                                      	                                              '                                                                 
                  #         '         
                           L   5                                                
      
         1                  	   	         %   !                   8   2      ;   /      3   >   &   ,   Ï   …      6   6   ;   >   3   š                     3                                                                                                                                         0                          
 	                                                                                                                                                                                                                                                             	                             	             (         0      
         	       #         3              	                '                       
      #   '   
         L 5                
  
   1      	 	   % !       8 2  ; /  3 > & , Ï …  6 6 ; > 3 š   ¡Ý  £‰  £µ  ¤  «  ³  ½g-‹E¥ò$&sB´Óï1ô
M4J`sˆ˜	ñkÙðÛïð'&8Iä@sÖw‚ÑÒ 0Òz#‘$7%I%÷%ô&š'›'å)2á!˜óG&�&P(¨ÙlÅÅjÀ#l»ë3ŠF)ƒ'×%þ“j!!'FÓƒ ¤1'æ ÜÜæ Úì%"•¤'Q&™&
0TæŒ:á	°
	ïOþ–©‚“¹ù'eå®
RÌÐ,ˆ”ÊWbw6j!î"*%œ%ß%Q&™&Ì&'!'­(ý())’†%}`Är'Ú Õ�È2Ùàá!¸'9 Ú Õ�Èê2—!á!Ú Õ�È2á!ÕÕ˜LóßF å 7&&@%Z¥" ' "G¤'jã1ÿ=ÓÖì	°M1)#é(Å˜Ó°ëãÓS[1Ž}S åñŽÆ	Ø%»m&5)r 
Í
æ?|M^	œ‹s Þ/¸ ’9z"÷	Ó"}™×} 
5HW¼Ú‘T2S'IK4	¦r6NÞ§!:aRû¬ ðe¡EâùûR¾û_tæ"š£%=‹ !ë	ï	Á  ‘È�>QÕ] ÿ%Ïxh¿Ýä!c›5Xpv±7 ±T	ú	O#“ðìoEâR¾I_tæKÉÓ)°x¶^%I(Û@)¥bZ3FZ(>Tj’Ë±Yõ˜UF›$$±YUF$$šúW‰Iärí5s6!	&V'2r£d á§±øYòáUF$$Á‘rZËÀãï¼åõ˜™§‚Õ´ÌI±$hðEâR¾_tæžŒ
U!ZŸ�ZjôV&ž&–�$`)Ó<)ÿ6>	Ýt$´!¾(â&¯2	½€cÔTEð –#U$ðEw¯âR¾_t°æj$Ü%LQaŠÞ'rs†mð e¡(Eâìü×½ùMûR¾û«_tÎæm» Ž!·!"%@%:&‚&6 
ç‹Œ!?|ŽÌuÙ"ô$×cî#r :xž!¢“Y[(Xu¥ÓÙçõUÍ¬	Y
–
q¢ûi‡n�Ûs-QŠÆ&J¸  |“ÒØ¾$6&~&ù&'%'V'C(˜(Ç).3§–§Û¾ ý#�$@)ë)‚õ €«!í	ÛéˆS\‘!@)„):

„3C'„EÍ6ë	ï	 >.$?&‡&ÛÔ¤Ê,(« m
î
•@k²!ë	ï	 >Ýr $µ%í)\Óêå	s&ù&²rZ£(>Tj’Ëd á§Àãï±¼øYåòõ˜á™§UF›$$Z1‘3«5žŽ"^%I(¥¬	Y
–
¢�sQ& ù&V'H–‘Æ	e
ÌØ%æLÆ
ˆ0:÷æ	í	9“_�7áíþ#VZ^bfjnÌÕ(�ˆÆ2Sq›Ëô~s!ú"*%O%¥%C&V&‹&ž&y'f(ù(Xis&¸ |Òù&˜(Ç)C]K�Zjôá^%V&ž&I(ë y¤LÃ7LKòQºaŠ9_pp"|"Ò"Ý"Þ'R('´)Å.%ë
½< ª'’s˜±X *|o ¸Fv.¢V"i"¼H!„$%‹ É&Þ&è&ó&ZËõ˜”ã¾v©)6 5
ç‹Xpv±7Œ! ±T	ú	?|O#§
ñ
ô
ü%R#A&‰&o¹šÚƒõ"Æ#!cX& &C6]ÊNÞ†²	þçl`p|Äf'–C4	F¦°Ök¦r{6]±ÃÊNYÞËUF<"$$^(º(5 w Å§²²„¿O"3˜=d0VŠÓ•H�/«5ž‹!Ž"Ø"+#�#ï#u$7'ë(W)8

²
r¯:PfŽ-Õ·äè# $í	ˆSÙ$ò	ò¢{�µ×l|–h#
$&‘)',Ðèf!&'WäcÔT$µ&6NÞ×xŽcWä¶ÌuÙ"î#ô$&¿¿×{ ¶%S
£ûÜŠC`¬3µZ1q‘_ Þ%4H R]Bbá€ 0H/ë yÈ¤]	eL0º_  p"Ò"(#Ä8Ló:q}"Þ"S(ÓÙçõUÍ	
AMqÙæßo~ÿl-Ç9“¾$Ë$D%7&n&&C(6)¹)*;]f)yÔŸ!,2êå¢	¢< R¡#&¦
»
ð
ó
;ö†°œ4œ©eô´·ÙÙ%…))ÞA ¯!÷"Å#È#	$¬%¾%&³ rsÖ˜Å¸üØWé=apÆÎz X!i!¸!v_kÛU»šØµØÍ,!ä#§(*LZ¥w»î&”!w"ÚJàÝMZ‡òû @(t)Øpz X!R#¦
»
ð
ó
;ö°œ4œ©e´)¯!	$¬%¾%&< ¡&†ô·ÙÙ%…)ÞA ÷"Å#È#Ä YN	ðs,”õêÎ&w)º õVˆ¶ÝpŒ# B!¾!)š @óƒ¶øÇK±ÛP}ºÒy#(�(—(Æ)< Ž ô ]R‚¡#&Qê	ñ	¦
»
ð
ó
;Ãö†û°ÿ(œ4œŸ©:eë´ôù€´·"=@ÙÉÙ%~…‘È)})qÞýâA \ ¯!÷"Å#È#	$˜$3%©%¬%¾%&!'vÓÙ_çõUÍ	
AMqÙæßo~ÿlkÛU-Ç»š9“ØµØÍ,!ä#¾$Ë$D%7&n&&C(§(6)¹)**? q¤’	4>Ó,¥KW¹ Z&¢&)Àhn3ë %q(Í cÎÿ6W>	†Ý¬u@t$\!>!´!J#Ì'²(¾(* 	 ¿#Ì#ã&ôUYÜA" A!ö!@ u Å è¥O	lñ„Ü°Ö4mºÏ&LÉÃæò?®\ñT P2#~�Žò"³"L$.'ÑßüüA	
å ø0œG=Ü!(F(:Y3&{&»&ß)ß JWDW{	Í
*T’,BXn–´Úh¿ÿ]ÛßÑô, /"h#>%…%Ô(T ÁL¼kPÉi	2[#~Ãæò?�®#Žò\Gñ"³"L$.'&Ùì€
“¾= À#Í#Ç%«'Ì ’és˜+AWm•\tõ±X ³!"±"*ƒ #Æ
ìç‹iH›É¸'•¾
p;�K·"ù$�'Ô)j ñW¡,1eÖ{Ð‹•ö%½&Ò&š'®)á) ú¢%‹áíùþEïtÇ0´*
	IÎ±GŽ-4ËEL=µòÙ:ç!ì#x%Ã%&¾'T)‚ 7"R9Oe�ª<ŠÝLÙ à!ú$Õ)ã M³6àOÊ*	V	`	ü	è%3;IQ_gu‡��Þ†ž/Ä
:¯¸�Öñkèòj u 3"º"@#¡$ï$-'x(°S	ÏÕÿ,Ý ´'„N\sw¦îl!u(ƒv~-	�ÏZxD C#y$)) ™._>²»II¼ÂðùLýÎR § á ,"G#»#ú#?(¯(s)P‘žŒc	Æ	e

UÆ!Z’Ì9‡z"Ø%ù	 I— Õ"m#z)ÇG4LµÙ:ç!Ã%t´*-ËEòì#¾'™²II¼ÂðLÎ á ?(s)ï0
	IÎ±Ž=x%&T)Ž ô ]‚Qê	ñ	Ãûÿ(Ÿ:ë´ù€"=@É~‘È}qýâ\ ˜$3%©%!'Ì &’ésÙì€
˜“+AWm•¾\tõ±= X ³!"±"À#Í#Ç%«'*10S¤É ø!AŽ†j¢Dã^"&%)Jz  ïÀÿ;ãó ;³*:<žø	BD}œ�j¶£!í"2%ø%ú%œ'º'í'·(ø()k Œ � ¥ ƒÙß	ò	hòX)¢-2{;ìfAÊ×|›ÉÑ~rŒ–½šãŠ #ž#Ž%£%ª%í%÷%¾&Ê&Ó&ß&é&ô&"'›'‘)¯)â) ô ]úQt¢ê	Ãû%ÿ‹Ÿáíùþ´ù?€"=½En~‘k
kýj·\ I!¤!#$…$˜$%3%Õ%»'�(L)3˜a­4_Ð
¶�²[íIE2ür’` ¤(G)½ TÛ9 Å%[‡	F	³	�
=mÿÌ<Wéè6«m	~ót¶.aq}‘ö™ÅÊÝ„ Ã '!0#1$_$¹$›%&1'g'ã(ü(� ò ñ:<¹
Fx”°ã0=§�÷S¿
C`u±çžiµ!c!ì"Y#$k$®$¼%Ý%ù%Ù'î'¶(÷()j)‡ ]×›‡i¿èq{	¬¦çÖ1BcI§ý&03%!t"q#W'ì zÜÉ�¥MÄ°^	m	÷	f8Má1œ2LóR×c» b‹:•<`qs ¡ ³ "q"}"Ë"Ó"Þ")#ß'S(é(³ s×#˜óË	ì	ð	Õ
½Å¸Ûý˜Â'½Äü’¡X’ÉêU3‚¥?=a€“ÇRÎÖ^ i!¹!ƒ#5%G%R% &' ')'T'w`¨î	IkÜêÛU¼š‰ET]Ø¶ØÍ¿ -!p!’!&#ä#þ#‘$§(A)…)ì)*D × ËÁQ€4LR^¬>‘t�¤¶F'&[kî¬õâ6Ÿ( L š ¤ �"_%W&Ÿ&ú&Â',(J(W(Ë(; ³ Ss½j æTÛzµ×#9K�˜ Åó%S[c|‡/yË		0	F	³	ì	ð	�
Õ
=Pmÿr˜½Ì<W–Åâé7y…¸ÓÛý*˜Âè'ž½Äìü6’¡«ÁÉäðXgm’½Éê	MU~�ó+3nt‚¥­¶.?aq}=‘æë$a€‹“Çö&H‘™¡ºÅ|—«5Rš¨ÎÖ(}�©ÊÝ^ „ Ã Í '!i!r!v!�!¹!Å!0#M#x#ƒ#Ä#$,$1$_$¹$%5%G%R%›%®% &&:&‚&ý&' ')'1'H'T'Z'g'x'((i(–(ã(ü(")‡)Å)D × Bk�ËÜË6@IOTpˆÊßé+XÁû^Qßëíòs	u	
)
+
1
´
ê
gz|ˆ¾«º€ÁÃ4LR^¬>PFHx‘t�¤¶F'&[k»Îîÿ0FY_fn�z¬Äõ@uâ)6“ŸÒ¯æ( 9 F L š ¤ Ð ó!C"E"G"�"¥#b$Ö$%_%N&W&–&Ÿ&·&ú&'ƒ'Â'å',(J(W(Ë( )Ï)1”8NdŒ•©G[4ZÈMJWLŒ!¡"\(> ¬ 	6Q•O£‘	n
ï
"“–N€Â=Al"d²Õ³U]emZó÷5VàG; “ T!®!ý"%$&P&Y&˜&¡&'`'O(Y( Ðõ·’¨9y:N~i«Àã
&
?
Ý
ý
ïö9B\n�sÈÕÞå"íMdœüìðL48vœ6 5!g"a&©&' É 
†4~È†	ñ1G]s…› Èî{ŠbÑ¿ÆGM>Ï58àŽ­d•­Ìã¼=È!"©#í$ð%%'+'þ'9 ;hø!wìGLwÃ	


–ý»b‰ž¿4¡Ù–·%ZuÇ„‡ºÛáçöŒ­1Ll‘ë3çëx F!´$Ï%''C'F'R'§' p ” Ü ¹Õå6€¦¶DGYyžÇå	ñc¤wBëï^¶ßî/·6tz/£!7!""W"e"j"ž"
&(ÿ(R ~ 1‰­½ÄB™1š ù#TÛ*î9x” Å%[‡	F	³	 
�
=^mØÿ ð!8NdŒÌ<W·éþ•a¥©¸Ðè:[
6G[«
4am¯	Z~íót’�¶Èß.Raq}�MŠ‘8JWrâöþ™ÅOjígÊÝì,LQŒ„ Ã !'!"v"¡"0#E#¨#1$@$S$_$‹$¹$ì$›%&p&1'g'ó'B(\(ã(ü(5)¸)� Â!?Q$½Ø¬7X^ÓÙ«OƒÖßåóNXü$ (Ï(   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  (ñ<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="0" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7787-7891" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="1" translationMW="31558.16" type="CDS" allowSegmentOverlaps="0" cleavageArrows="7960" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment name="signal sequence" range="7892-7960" color="#ccffcc" type="standard" translated="1"/><Segment range="7961-8752" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="2" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8923-9511" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="SP6 promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6981-6999" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage SP6 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5238-5948" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MVSKGEEDNMAIIKEFMRFKVHMEGSVNGHEFEIEGEGEGRPYEGTQTAKLKVTKGGPLPFAWDILSPQFMYGSKAYVKHPADIPDYLKLSFPEGFKWERVMNFEDGGVVTVTQDSSLQDGEFIYKVKLRGTNFPSDGPVMQKKTMGWEASSERMYPEDGALKGEIKQRLKLKDGGHYDAEVKTTYKAKKPVQLPGAYNVNIKLDITSHNEDYTIVEQYERAEGRHSTGGMDELYK*"/></Q></Feature><Feature recentID="5" name="TagBFP" directionality="1" translationMW="26283.53" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3894-4595" color="#3366ff" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric blue fluorescent protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSELIKENMHMKLYMEGTVDNHHFKCTSEGEGKPYEGTQTMRIKVVEGGPLPFAFDILATSFLYGSKTFINHTQGIPDFFKQSFPEGFTWERVTTYEDGGVLTATQDTSLQDGCLIYNVKIRGVNFTSNGPVMQKKTLGWEAFTETLYPADGGLEGRNDMALKLVGGSHLIANIKTTYRSKKPAKNLKMPGVYYVDYRLERIKEANNETYVEQHEVAVARYCDLPSKLGHKLN*"/></Q></Feature><Feature recentID="6" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9757-10086" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9937-10072" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="small t intron" type="intron" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="455-520" color="noColor" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 (simian virus 40) small t antigen intron&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="1072" maxFusedRunOn="1072" detectionMode="exactProteinMatch"><Segment range="650-670" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="PKKKRKV"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1095-1229" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="PGK promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4718-5217" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mouse phosphoglycerate kinase 1 promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6025-6613" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="3' LTR" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1397-2030" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6723-6956" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2077-2202" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2699-2932" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3446-3563" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="gp41 peptide" directionality="1" translationMW="1816.08" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3758" maxFusedRunOn="3758" detectionMode="exactProteinMatch"><Segment range="3117-3161" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;recognized by the 2H10 single-chain llama nanobody&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;antigenic peptide corresponding to amino acids 655 to 669 of the HIV envelope protein gp41 (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/23505368&quot;&gt;Lutje Hulsik et al., 2013&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="KNEQELLELDKWASL"/></Q></Feature><Feature recentID="19" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6495" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="6421" maxFusedRunOn="6421" detectionMode="exactProteinMatch"><Segment range="6496-6507" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="IEGR"/></Q></Feature><Feature recentID="20" name="KS primer" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6616-6632" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
  .Í<?xml version="1.0"?><Primers nextValidID="19"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="Amp-R" sequence="ATAATACCGCGCCACATAGC" description="Ampicillin resistance gene, reverse primer"><BindingSite location="8109-8128" boundStrand="1" annealedBases="ATAATACCGCGCCACATAGC" meltingTemperature="58"><Component hybridizedRange="8109-8128" bases="ATAATACCGCGCCACATAGC"/></BindingSite><BindingSite simplified="1" location="8109-8128" boundStrand="1" annealedBases="ATAATACCGCGCCACATAGC" meltingTemperature="58"><Component hybridizedRange="8109-8128" bases="ATAATACCGCGCCACATAGC"/></BindingSite></Primer><Primer recentID="1" name="EBV-rev" sequence="GTGGTTTGTCCAAACTCATC" description="SV40 polyA terminator, reverse primer"><BindingSite location="1185-1204" boundStrand="0" annealedBases="GTGGTTTGTCCAAACTCATC" meltingTemperature="55"><Component hybridizedRange="1185-1204" bases="GTGGTTTGTCCAAACTCATC"/></BindingSite><BindingSite simplified="1" location="1185-1204" boundStrand="0" annealedBases="GTGGTTTGTCCAAACTCATC" meltingTemperature="55"><Component hybridizedRange="1185-1204" bases="GTGGTTTGTCCAAACTCATC"/></BindingSite></Primer><Primer recentID="2" name="L4440" sequence="AGCGAGTCAGTGAGCGAG" description="L4440 vector, forward primer"><BindingSite location="9664-9681" boundStrand="0" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="9664-9681" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite><BindingSite simplified="1" location="9664-9681" boundStrand="0" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="9664-9681" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite></Primer><Primer recentID="3" name="LNCX" sequence="AGCTCGTTTAGTGAACCGTCAGATC" description="Human CMV promoter, forward primer"><BindingSite location="3788-3812" boundStrand="0" annealedBases="AGCTCGTTTAGTGAACCGTCAGATC" meltingTemperature="60"><Component hybridizedRange="3788-3812" bases="AGCTCGTTTAGTGAACCGTCAGATC"/></BindingSite><BindingSite simplified="1" location="3788-3812" boundStrand="0" annealedBases="AGCTCGTTTAGTGAACCGTCAGATC" meltingTemperature="60"><Component hybridizedRange="3788-3812" bases="AGCTCGTTTAGTGAACCGTCAGATC"/></BindingSite></Primer><Primer recentID="4" name="mCherry-F" sequence="CCCCGTAATGCAGAAGAAGA" description="mCherry, forward primer"><BindingSite location="5650-5669" boundStrand="0" annealedBases="CCCCGTAATGCAGAAGAAGA" meltingTemperature="54"><Component hybridizedRange="5650-5669" bases="CCCCGTAATGCAGAAGAAGA"/></BindingSite><BindingSite simplified="1" location="5650-5669" boundStrand="0" annealedBases="CCCCGTAATGCAGAAGAAGA" meltingTemperature="54"><Component hybridizedRange="5650-5669" bases="CCCCGTAATGCAGAAGAAGA"/></BindingSite></Primer><Primer recentID="5" name="mCherry-R" sequence="TTGGTCACCTTCAGCTTGG" description="mCherry, reverse primer"><BindingSite location="5382-5400" boundStrand="1" annealedBases="TTGGTCACCTTCAGCTTGG" meltingTemperature="57"><Component hybridizedRange="5382-5400" bases="TTGGTCACCTTCAGCTTGG"/></BindingSite><BindingSite simplified="1" location="5382-5400" boundStrand="1" annealedBases="TTGGTCACCTTCAGCTTGG" meltingTemperature="57"><Component hybridizedRange="5382-5400" bases="TTGGTCACCTTCAGCTTGG"/></BindingSite></Primer><Primer recentID="6" name="mPGK-F" sequence="CATTCTGCACGCTTCAAAAG" description="Mouse PGK promoter, forward primer"><BindingSite location="5149-5168" boundStrand="0" annealedBases="CATTCTGCACGCTTCAAAAG" meltingTemperature="55"><Component hybridizedRange="5149-5168" bases="CATTCTGCACGCTTCAAAAG"/></BindingSite><BindingSite simplified="1" location="5149-5168" boundStrand="0" annealedBases="CATTCTGCACGCTTCAAAAG" meltingTemperature="55"><Component hybridizedRange="5149-5168" bases="CATTCTGCACGCTTCAAAAG"/></BindingSite></Primer><Primer recentID="7" name="MSCV-rev" sequence="CAGCGGGGCTGCTAAAGCGCATGC" description="Murine stem cell virus, reverse primer"><BindingSite location="4752-4775" boundStrand="1" annealedBases="CAGCGGGGCTGCTAAAGCGCATGC" meltingTemperature="69"><Component hybridizedRange="4752-4775" bases="CAGCGGGGCTGCTAAAGCGCATGC"/></BindingSite><BindingSite simplified="1" location="4752-4775" boundStrand="1" annealedBases="CAGCGGGGCTGCTAAAGCGCATGC" meltingTemperature="69"><Component hybridizedRange="4752-4775" bases="CAGCGGGGCTGCTAAAGCGCATGC"/></BindingSite></Primer><Primer recentID="8" name="pBABE 3'" sequence="ACCCTAACTGACACACATTCC" description="SV40 enhancer, reverse primer for pBABE vectors"><BindingSite location="4811-4820" boundStrand="0" annealedBases="CACACATTCC" meltingTemperature="34"><Component bases="ACCCTAACTGA"/><Component hybridizedRange="4811-4820" bases="CACACATTCC"/></BindingSite><BindingSite location="9751-9771" boundStrand="1" annealedBases="ACCCTAACTGACACACATTCC" meltingTemperature="56"><Component hybridizedRange="9751-9771" bases="ACCCTAACTGACACACATTCC"/></BindingSite><BindingSite simplified="1" location="4811-4820" boundStrand="0" annealedBases="CACACATTCC" meltingTemperature="34"><Component bases="ACCCTAACTGA"/><Component hybridizedRange="4811-4820" bases="CACACATTCC"/></BindingSite><BindingSite simplified="1" location="9751-9771" boundStrand="1" annealedBases="ACCCTAACTGACACACATTCC" meltingTemperature="56"><Component hybridizedRange="9751-9771" bases="ACCCTAACTGACACACATTCC"/></BindingSite></Primer><Primer recentID="9" name="pBluescriptKS" sequence="TCGAGGTCGACGGTATC" description="For pBluescript vector"><BindingSite location="3409-3419" boundStrand="0" annealedBases="TCGACGGTATC" meltingTemperature="35"><Component bases="TCGAGG"/><Component hybridizedRange="3409-3419" bases="TCGACGGTATC"/></BindingSite><BindingSite location="6616-6632" boundStrand="1" annealedBases="TCGAGGTCGACGGTATC" meltingTemperature="54"><Component hybridizedRange="6616-6632" bases="TCGAGGTCGACGGTATC"/></BindingSite><BindingSite simplified="1" location="3409-3419" boundStrand="0" annealedBases="TCGACGGTATC" meltingTemperature="35"><Component bases="TCGAGG"/><Component hybridizedRange="3409-3419" bases="TCGACGGTATC"/></BindingSite><BindingSite simplified="1" location="6616-6632" boundStrand="1" annealedBases="TCGAGGTCGACGGTATC" meltingTemperature="54"><Component hybridizedRange="6616-6632" bases="TCGAGGTCGACGGTATC"/></BindingSite></Primer><Primer recentID="10" name="pBR322ori-F" sequence="GGGAAACGCCTGGTATCTTT" description="pBR322 origin, forward primer"><BindingSite location="9411-9430" boundStrand="0" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="9411-9430" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite><BindingSite simplified="1" location="9411-9430" boundStrand="0" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="9411-9430" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite></Primer><Primer recentID="11" name="pBRforEco" sequence="AATAGGCGTATCACGAGGC" description="pBR322 vectors, upsteam of EcoRI site, forward primer"><BindingSite location="7700-7718" boundStrand="1" annealedBases="AATAGGCGTATCACGAGGC" meltingTemperature="57"><Component hybridizedRange="7700-7718" bases="AATAGGCGTATCACGAGGC"/></BindingSite><BindingSite simplified="1" location="7700-7718" boundStrand="1" annealedBases="AATAGGCGTATCACGAGGC" meltingTemperature="57"><Component hybridizedRange="7700-7718" bases="AATAGGCGTATCACGAGGC"/></BindingSite></Primer><Primer recentID="12" name="pBRrevBam" sequence="GGTGATGTCGGCGATATAGG" description="pBR322 vectors, tet region, downstream of BamHI, reverse primer"><BindingSite location="7288-7307" boundStrand="1" annealedBases="GGTGATGTCGGCGATATAGG" meltingTemperature="57"><Component hybridizedRange="7288-7307" bases="GGTGATGTCGGCGATATAGG"/></BindingSite><BindingSite simplified="1" location="7288-7307" boundStrand="1" annealedBases="GGTGATGTCGGCGATATAGG" meltingTemperature="57"><Component hybridizedRange="7288-7307" bases="GGTGATGTCGGCGATATAGG"/></BindingSite></Primer><Primer recentID="13" name="pGEX 3'" sequence="CCGGGAGCTGCATGTGTCAGAGG" description="pGEX vectors, reverse primer"><BindingSite location="7640-7662" boundStrand="0" annealedBases="CCGGGAGCTGCATGTGTCAGAGG" meltingTemperature="66"><Component hybridizedRange="7640-7662" bases="CCGGGAGCTGCATGTGTCAGAGG"/></BindingSite><BindingSite simplified="1" location="7640-7662" boundStrand="0" annealedBases="CCGGGAGCTGCATGTGTCAGAGG" meltingTemperature="66"><Component hybridizedRange="7640-7662" bases="CCGGGAGCTGCATGTGTCAGAGG"/></BindingSite></Primer><Primer recentID="14" name="pRS-marker" sequence="CGGCATCAGAGCAGATTGTA" description="pRS vectors, use to sequence yeast selectable marker"><BindingSite location="7521-7540" boundStrand="1" annealedBases="CGGCATCAGAGCAGATTGTA" meltingTemperature="54"><Component hybridizedRange="7521-7540" bases="CGGCATCAGAGCAGATTGTA"/></BindingSite><BindingSite simplified="1" location="7521-7540" boundStrand="1" annealedBases="CGGCATCAGAGCAGATTGTA" meltingTemperature="54"><Component hybridizedRange="7521-7540" bases="CGGCATCAGAGCAGATTGTA"/></BindingSite></Primer><Primer recentID="15" name="SP6" sequence="ATTTAGGTGACACTATAG" description="SP6 promoter, forward primer"><BindingSite location="6981-6998" boundStrand="1" annealedBases="ATTTAGGTGACACTATAG" meltingTemperature="44"><Component hybridizedRange="6981-6998" bases="ATTTAGGTGACACTATAG"/></BindingSite><BindingSite simplified="1" location="6981-6998" boundStrand="1" annealedBases="ATTTAGGTGACACTATAG" meltingTemperature="44"><Component hybridizedRange="6981-6998" bases="ATTTAGGTGACACTATAG"/></BindingSite></Primer><Primer recentID="16" name="SV40pA-R" sequence="GAAATTTGTGATGCTATTGC" description="SV40 polyA, reverse primer"><BindingSite location="6127-6136" boundStrand="0" annealedBases="ATGCTATTGC" meltingTemperature="32"><Component bases="GAAATTTGTG"/><Component hybridizedRange="6127-6136" bases="ATGCTATTGC"/></BindingSite><BindingSite location="1131-1150" boundStrand="1" annealedBases="GAAATTTGTGATGCTATTGC" meltingTemperature="52"><Component hybridizedRange="1131-1150" bases="GAAATTTGTGATGCTATTGC"/></BindingSite><BindingSite simplified="1" location="6127-6136" boundStrand="0" annealedBases="ATGCTATTGC" meltingTemperature="32"><Component bases="GAAATTTGTG"/><Component hybridizedRange="6127-6136" bases="ATGCTATTGC"/></BindingSite><BindingSite simplified="1" location="1131-1150" boundStrand="1" annealedBases="GAAATTTGTGATGCTATTGC" meltingTemperature="52"><Component hybridizedRange="1131-1150" bases="GAAATTTGTGATGCTATTGC"/></BindingSite></Primer><Primer recentID="17" name="SV40pro-F" sequence="TATTTATGCAGAGGCCGAGG" description="SV40 promoter/origin, forward primer"><BindingSite location="9998-10017" boundStrand="0" annealedBases="TATTTATGCAGAGGCCGAGG" meltingTemperature="57"><Component hybridizedRange="9998-10017" bases="TATTTATGCAGAGGCCGAGG"/></BindingSite><BindingSite location="10021-10032" boundStrand="1" annealedBases="CAGAGGCCGAGG" meltingTemperature="51"><Component bases="TATTTATG"/><Component hybridizedRange="10021-10032" bases="CAGAGGCCGAGG"/></BindingSite><BindingSite simplified="1" location="9998-10017" boundStrand="0" annealedBases="TATTTATGCAGAGGCCGAGG" meltingTemperature="57"><Component hybridizedRange="9998-10017" bases="TATTTATGCAGAGGCCGAGG"/></BindingSite><BindingSite simplified="1" location="10021-10032" boundStrand="1" annealedBases="CAGAGGCCGAGG" meltingTemperature="51"><Component bases="TATTTATG"/><Component hybridizedRange="10021-10032" bases="CAGAGGCCGAGG"/></BindingSite></Primer><Primer recentID="18" name="WPRE-R" sequence="CATAGCGTAAAAGGAGCAACA" description="WPRE, reverse primer"><BindingSite location="6077-6097" boundStrand="1" annealedBases="CATAGCGTAAAAGGAGCAACA" meltingTemperature="55"><Component hybridizedRange="6077-6097" bases="CATAGCGTAAAAGGAGCAACA"/></BindingSite><BindingSite simplified="1" location="6077-6097" boundStrand="1" annealedBases="CATAGCGTAAAAGGAGCAACA" meltingTemperature="55"><Component hybridizedRange="6077-6097" bases="CATAGCGTAAAAGGAGCAACA"/></BindingSite></Primer></Primers>
  ü<Notes>
<UUID>d9a01c5b-32ca-4633-8789-8e120bb698b7</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pHR_Gal4UAS_tBFP_PGK_mCherry</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>Lentiviral vector - tBFP reporter for Gal4DBDVP64 synNotch receptors with a constitutive mCherry.</Description>
<Created UTC="20:44:40">2021.5.12</Created>
<LastModified UTC="20:44:40">2021.5.12</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
<References>
<Reference type="Journal Article" authors="Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA" pubMedID="26830878" date="2016-02-11- 11" pages="780-91" issue="4" journal="Cell. 2016 Feb 11;164(4):780-91. doi: 10.1016/j.cell.2016.01.012. Epub 2016 Jan 28." title="Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors." journalName="Cell" doi="10.1016/j.cell.2016.01.012" volume="164"/>
</References>
</Notes>
  Y     –         
?????                                                                                                       ÿ d      HO  d               E              ÿÿÿÿYô? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
